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pentobarbital will reduce the level or effect of hydrocortisone by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Observe.pentobarbital decreases levels of elvitegravir/cobicistat/emtricitabine/tenofovir DF by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Contraindicated. Might produce loss of virologic reaction and d